Common Severe Infections in Chronic Granulomatous Disease
Author(s) -
B. E. Marciano,
Christine Spalding,
Avril A. Fitzgerald,
Douglas L. Mann,
Trevor S. Brown,
Sharon Osgood,
Lynne Yockey,
Dirk Darnell,
Lisa Barnhart,
Jennifer Daub,
Lisa Boris,
Amy Rump,
Virgil L. Anderson,
Courtney Haney,
Douglas B. Kuhns,
Sergio D. Rosenzweig,
Corin Kelly,
Adrian M. Zelazny,
Thomas Mason,
Suk See De Ravin,
Elizabeth M. Kang,
John I. Gallin,
Harry L. Malech,
K.N. Olivier,
Gülbû Uzel,
Alexandra F. Freeman,
Theo Heller,
Christa S. Zerbe,
Steven M. Holland
Publication year - 2014
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciu1154
Subject(s) - medicine , chronic granulomatous disease , aspergillosis , serratia , nocardia , gastroenterology , surgery , immunology , biology , bacteria , pseudomonas , genetics
Chronic granulomatous disease (CGD) is due to defective nicotinamide adenine dinucleotide phosphate oxidase activity and characterized by recurrent infections with a limited spectrum of bacteria and fungi as well as inflammatory complications. To understand the impact of common severe infections in CGD, we examined the records of 268 patients followed at a single center over 4 decades.
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