Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness | Zendy

Martin Walker | Zendy; Sabine Specht | Zendy; Thomas S. Churcher | Zendy; Achim Hoerauf | Zendy; Mark J. Taylor | Zendy; Marı́a-Gloria Basáñez | Zendy

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Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness

Author(s) -

Martin Walker,

Sabine Specht,

Thomas S. Churcher,

Achim Hoerauf,

Mark J. Taylor,

Marı́a-Gloria Basáñez

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu1152

Subject(s) - doxycycline , wolbachia , onchocerciasis , medicine , onchocerca volvulus , clinical trial , filariasis , artemether , antibiotics , pharmacology , immunology , biology , helminths , microbiology and biotechnology , ecology , plasmodium falciparum , artemisinin , malaria , host (biology)

Onchocerca volvulus and lymphatic filariae, causing river blindness and elephantiasis, depend on endosymbiotic Wolbachia bacteria for growth, development, fertility, and survival. Clinical trials have shown that doxycycline treatment eliminates Wolbachia, causing long-term sterilization of adult female filariae and effecting potent macrofilaricidal activity. The continual reinfection by drug-naive worms that occurs in these trial settings dilutes observable anti-Wolbachia and antifilarial effects, making it difficult to estimate therapeutic efficacy and compare different doxycycline regimens, evaluated at different times after treatment.

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