An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution | Zendy

Claire S. Waddington | Zendy; Thomas C. Darton | Zendy; Claire Jones | Zendy; Kathryn Haworth | Zendy; Anna L. Peters | Zendy; Tessa M. John | Zendy; Ben Thompson | Zendy; Simon Kerridge | Zendy; Robert A. Kingsley | Zendy; Liqing Zhou | Zendy; Kathryn E. Holt | Zendy; LyMee Yu | Zendy; Stephen Lockhart | Zendy; Jeremy Farrar | Zendy; Marcelo B. Sztein | Zendy; Gordon Dougan | Zendy; Brian Angus | Zendy; Myron M. Levine | Zendy; Andrew J. Pollard | Zendy

Open Access

An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution

Author(s) -

Claire S. Waddington,

Thomas C. Darton,

Claire Jones,

Kathryn Haworth,

Anna L. Peters,

Tessa M. John,

Ben Thompson,

Simon Kerridge,

Robert A. Kingsley,

Liqing Zhou,

Kathryn E. Holt,

LyMee Yu,

Stephen Lockhart,

Jeremy Farrar,

Marcelo B. Sztein,

Gordon Dougan,

Brian Angus,

Myron M. Levine,

Andrew J. Pollard

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu078

Subject(s) - medicine , sodium bicarbonate , salmonella typhi , salmonella , outpatient clinic , bacteria , genetics , biology , gene , biochemistry , chemistry , escherichia coli

Typhoid fever is a major global health problem, the control of which is hindered by lack of a suitable animal model in which to study Salmonella Typhi infection. Until 1974, a human challenge model advanced understanding of typhoid and was used in vaccine development. We set out to establish a new human challenge model and ascertain the S. Typhi (Quailes strain) inoculum required for an attack rate of 60%-75% in typhoid-naive volunteers when ingested with sodium bicarbonate solution.

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