Herpes Zoster Caused by Vaccine-Strain Varicella Zoster Virus in an Immunocompetent Recipient of Zoster Vaccine | Zendy

Hung Fu Tseng | Zendy; D. Scott Schmid | Zendy; Rafael Harpaz | Zendy; Phillip LaRussa | Zendy; Nancy J. Jensen | Zendy; Pierre Rivailler | Zendy; Kristen J. Radford | Zendy; Jason P. Folster | Zendy; Steven J. Jacobsen | Zendy

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Herpes Zoster Caused by Vaccine-Strain Varicella Zoster Virus in an Immunocompetent Recipient of Zoster Vaccine

Author(s) -

Hung Fu Tseng,

D. Scott Schmid,

Rafael Harpaz,

Phillip LaRussa,

Nancy J. Jensen,

Pierre Rivailler,

Kristen J. Radford,

Jason P. Folster,

Steven J. Jacobsen

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu058

Subject(s) - virology , medicine , varicella zoster virus , chickenpox vaccine , varicella vaccine , virus , strain (injury) , herpesviridae , attenuated vaccine , immunization , viral disease , immunology , virulence , biology , antibody , gene , genetics

We report the first laboratory-documented case of herpes zoster caused by the attenuated varicella zoster virus (VZV) contained in Zostavax in a 68-year-old immunocompetent adult with strong evidence of prior wild-type VZV infection. The complete genome sequence of the isolate revealed that the strain carried 15 of 42 (36%) recognized varicella vaccine-associated single-nucleotide polymorphisms, including all 5 of the fixed vaccine markers present in nearly all of the strains in the vaccine. The case of herpes zoster was relatively mild and resolved without complications.

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