DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients? | Zendy

Jason A. Roberts | Zendy; Sanjoy K. Paul | Zendy; Murat Akova | Zendy; Matteo Bassetti | Zendy; Jan J. De Waele | Zendy; George Dimοpoulos | Zendy; Kirsi-Maija Kaukonen | Zendy; Despoina Koulenti | Zendy; Claudio M. Martin | Zendy; P. Montravers | Zendy; Jordi Rello | Zendy; Andrew Rhodes | Zendy; T. Starr | Zendy; S. C. Wallis | Zendy; Jeffrey Lipman | Zendy; Steven C. Wallis | Zendy; A. S. Margarit | Zendy; Luc De Crop | Zendy; Herbert Spapen | Zendy; Joost Wauters | Zendy; Thierry Dugernier | Zendy; Philippe G. Jorens | Zendy; I. Dapper | Zendy; Daniel De Backer | Zendy; Fabio Silvio Taccone | Zendy; Laura Ruano | Zendy; Elsa Afonso | Zendy; Francisco Álvarez-Lerma | Zendy; M.P. Gracia-Arnillas | Zendy; Francisco Arnalich | Zendy; Nícolas de Albuquerque Pereira Feijóo | Zendy; N. Bardolet | Zendy; A Rovira | Zendy; Pau Garro | Zendy; Diego Colón | Zendy; C. Castillo | Zendy; J. Fernado | Zendy; María José López | Zendy; José Luís Fernández | Zendy; Alfredo Arribas | Zendy; J. L. Teja | Zendy; Elsa Ots | Zendy; Juan Carlos Montejo | Zendy; M. S. Catalán | Zendy; I. Prieto | Zendy; G. Gonzalo | Zendy; Beatriz Galván | Zendy; M. A. Blasco | Zendy; EC Meyer | Zendy; F. Del Nogal | Zendy; Loreto Vidaur | Zendy; Rafael Sebastián | Zendy; P. M. Garde | Zendy; M. d. M. Martin Velasco | Zendy; Rafael Zaragoza | Zendy; M. Esperatti | Zendy; A. Torres | Zendy; Olivier Baldési | Zendy; H. Dupont | Zendy; Yazine Mahjoub | Zendy; Sigismond Lasocki | Zendy; Jean-Michel Constantin | Zendy; JeanFrançois Payen | Zendy; J. Albanèse | Zendy; Yannick Mallédant | Zendy; Julien Pottecher | Zendy; Jean Yves Lefrant | Zendy; S. Jaber | Zendy; O. Joannes-Boyau | Zendy; Carmen Orban | Zendy; Marlies Ostermann | Zendy; Cathrine McKenzie | Zendy; W. R. Berry | Zendy; Julie Smith | Zendy; K Lei | Zendy; Francesca Rubulotta | Zendy; Anthony Gordon | Zendy; Stephen J. Brett | Zendy; M. Stotz | Zendy; M. Templeton | Zendy; Claudia Ebm | Zendy; Cristiane Aparecida Moran | Zendy; Ville Pettilä | Zendy; A. Xristodoulou | Zendy; Vasiliki Theodorou | Zendy; Georgios Kouliatsis | Zendy; Eleni Sertaridou | Zendy; George Anthopoulos | Zendy; G. Choutas | Zendy; T. Rantis | Zendy; Stylianos Karatzas | Zendy; Margarita Balla | Zendy; Metaxia Papanikolaou | Zendy; Pavlos Myrianthefs | Zendy; Alexandra Gavala | Zendy; G. Fildisis | Zendy; Antonia Koutsoukou | Zendy; Magdalini Kyriakopoulou | Zendy; Kalomira Petrochilou | Zendy; Maria Kompoti | Zendy; Martha Michalia | Zendy; F.-M. Clouva-Molyvdas | Zendy; George Gkiokas | Zendy; F. Nikolakopoulos | Zendy; V. Psychogiou | Zendy; Polychronis Malliotakis | Zendy; E. Akoumianaki | Zendy; Emmanuel Lilitsis | Zendy; Vasilios Koulouras | Zendy; George Nakos | Zendy; Maria Kalogirou | Zendy; Apostolos Komnos | Zendy; Tilemachos Zafeiridis | Zendy; C. Chaintoutis | Zendy; Kostoula Arvaniti | Zendy; Dimitris Matamis | Zendy; C. Kydona | Zendy; N. Gritsi-Gerogianni | Zendy; T. Giasnetsova | Zendy; M. Giannakou | Zendy; Ioanna Soultati | Zendy; Ilias Chytas | Zendy; E Antoniadou | Zendy; E. Antipa | Zendy; Dimitrios Lathyris | Zendy; Triantafyllia Koukoubani | Zendy; Theoniki Paraforou | Zendy; K. Spiropoulou | Zendy; Vasileios Bekos | Zendy; Alexander M. Spring | Zendy; T. Kalatzi | Zendy; H. Nikolaou | Zendy; M Laskou | Zendy; Ioannis Strouvalis | Zendy; Stavros Aloizos | Zendy; S. Kapogiannis | Zendy; O. Soldatou | Zendy; Chiara Adembri | Zendy; Gianluca Villa | Zendy; Antonino Giarratano | Zendy; Santi Maurizio Raineri | Zendy; Andrea Cortegiani | Zendy; Francesca Montalto | Zendy; Maria Teresa Strano | Zendy; V. Marco Ranieri | Zendy; Claudio Sandroni | Zendy; Gennaro De Pascale | Zendy; Alexandre Molin | Zendy; Paolo Pelosi | Zendy; L. Montagnani | Zendy; Rosario Urbino | Zendy; Ilaria Mastromauro | Zendy; Francesco Giuseppe De Rosa | Zendy; Teresa Cardoso | Zendy; Susana Afonso | Zendy; João Gonçalves-Pereira | Zendy; J. P. Baptista | Zendy; Ahmet Özveren | Zendy

Open Access

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

Author(s) -

Jason A. Roberts,

Sanjoy K. Paul,

Murat Akova,

Matteo Bassetti,

Jan J. De Waele,

George Dimοpoulos,

Kirsi-Maija Kaukonen,

Despoina Koulenti,

Claudio M. Martin,

P. Montravers,

Jordi Rello,

Andrew Rhodes,

T. Starr,

S. C. Wallis,

Jeffrey Lipman,

Steven C. Wallis,

A. S. Margarit,

Luc De Crop,

Herbert Spapen,

Joost Wauters,

Thierry Dugernier,

Philippe G. Jorens,

I. Dapper,

Daniel De Backer,

Fabio Silvio Taccone,

Laura Ruano,

Elsa Afonso,

Francisco Álvarez-Lerma,

M.P. Gracia-Arnillas,

Francisco Arnalich,

Nícolas de Albuquerque Pereira Feijóo,

N. Bardolet,

A Rovira,

Pau Garro,

Diego Colón,

C. Castillo,

J. Fernado,

María José López,

José Luís Fernández,

Alfredo Arribas,

J. L. Teja,

Elsa Ots,

Juan Carlos Montejo,

M. S. Catalán,

I. Prieto,

G. Gonzalo,

Beatriz Galván,

M. A. Blasco,

EC Meyer,

F. Del Nogal,

Loreto Vidaur,

Rafael Sebastián,

P. M. Garde,

M. d. M. Martin Velasco,

Rafael Zaragoza,

M. Esperatti,

A. Torres,

Olivier Baldési,

H. Dupont,

Yazine Mahjoub,

Sigismond Lasocki,

Jean-Michel Constantin,

JeanFrançois Payen,

J. Albanèse,

Yannick Mallédant,

Julien Pottecher,

Jean Yves Lefrant,

S. Jaber,

O. Joannes-Boyau,

Carmen Orban,

Marlies Ostermann,

Cathrine McKenzie,

W. R. Berry,

Julie Smith,

K Lei,

Francesca Rubulotta,

Anthony Gordon,

Stephen J. Brett,

M. Stotz,

M. Templeton,

Claudia Ebm,

Cristiane Aparecida Moran,

Ville Pettilä,

A. Xristodoulou,

Vasiliki Theodorou,

Georgios Kouliatsis,

Eleni Sertaridou,

George Anthopoulos,

G. Choutas,

T. Rantis,

Stylianos Karatzas,

Margarita Balla,

Metaxia Papanikolaou,

Pavlos Myrianthefs,

Alexandra Gavala,

G. Fildisis,

Antonia Koutsoukou,

Magdalini Kyriakopoulou,

Kalomira Petrochilou,

Maria Kompoti,

Martha Michalia,

F.-M. Clouva-Molyvdas,

George Gkiokas,

F. Nikolakopoulos,

V. Psychogiou,

Polychronis Malliotakis,

E. Akoumianaki,

Emmanuel Lilitsis,

Vasilios Koulouras,

George Nakos,

Maria Kalogirou,

Apostolos Komnos,

Tilemachos Zafeiridis,

C. Chaintoutis,

Kostoula Arvaniti,

Dimitris Matamis,

C. Kydona,

N. Gritsi-Gerogianni,

T. Giasnetsova,

M. Giannakou,

Ioanna Soultati,

Ilias Chytas,

E Antoniadou,

E. Antipa,

Dimitrios Lathyris,

Triantafyllia Koukoubani,

Theoniki Paraforou,

K. Spiropoulou,

Vasileios Bekos,

Alexander M. Spring,

T. Kalatzi,

H. Nikolaou,

M Laskou,

Ioannis Strouvalis,

Stavros Aloizos,

S. Kapogiannis,

O. Soldatou,

Chiara Adembri,

Gianluca Villa,

Antonino Giarratano,

Santi Maurizio Raineri,

Andrea Cortegiani,

Francesca Montalto,

Maria Teresa Strano,

V. Marco Ranieri,

Claudio Sandroni,

Gennaro De Pascale,

Alexandre Molin,

Paolo Pelosi,

L. Montagnani,

Rosario Urbino,

Ilaria Mastromauro,

Francesco Giuseppe De Rosa,

Teresa Cardoso,

Susana Afonso,

João Gonçalves-Pereira,

J. P. Baptista,

Ahmet Özveren

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu027

Subject(s) - medicine , dosing , antibiotics , interquartile range , intensive care unit , odds ratio , pharmacodynamics , prospective cohort study , confidence interval , pharmacokinetics , intensive care , intensive care medicine , microbiology and biotechnology , biology

Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affect patient outcome.

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