Long-term Persistence of Immunity and B-Cell Memory Following Haemophilus influenzae Type b Conjugate Vaccination in Early Childhood and Response to Booster | Zendy

Kirsten P. Perrett | Zendy; Tessa M. John | Zendy; Celina Jin | Zendy; Elizabeth Kibwana | Zendy; LyMee Yu | Zendy; Nigel Curtis | Zendy; Andrew J. Pollard | Zendy

Open Access

Long-term Persistence of Immunity and B-Cell Memory Following Haemophilus influenzae Type b Conjugate Vaccination in Early Childhood and Response to Booster

Author(s) -

Kirsten P. Perrett,

Tessa M. John,

Celina Jin,

Elizabeth Kibwana,

LyMee Yu,

Nigel Curtis,

Andrew J. Pollard

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu001

Subject(s) - hib vaccine , medicine , booster (rocketry) , vaccination , booster dose , haemophilus influenzae , immunity , immunization , immunology , conjugate vaccine , antibody , pasteurellaceae , pediatrics , virology , immune system , microbiology and biotechnology , biology , antibiotics , physics , astronomy

Protection against Haemophilus influenzae type b (Hib), a rapidly invading encapsulated bacteria, is dependent on maintenance of an adequate level of serum antibody through early childhood. In many countries, Hib vaccine booster doses have been implemented after infant immunization to sustain immunity. We investigated the long-term persistence of antibody and immunological memory in primary-school children following infant (with or without booster) Hib vaccination.

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