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Protection against Haemophilus influenzae type b (Hib), a rapidly invading encapsulated bacteria, is dependent on maintenance of an adequate level of serum antibody through early childhood. In many countries, Hib vaccine booster doses have been implemented after infant immunization to sustain immunity. We investigated the long-term persistence of antibody and immunological memory in primary-school children following infant (with or without booster) Hib vaccination.

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

Long-term Persistence of Immunity and B-Cell Memory Following Haemophilus influenzae Type b Conjugate Vaccination in Early Childhood and Response to Booster