Xenodiagnosis to Detect Borrelia burgdorferi Infection: A First-in-Human Study | Zendy

Adriana Marques | Zendy; Sam R. Telford | Zendy; Siu-Ping Turk | Zendy; Erin Chung | Zendy; Carla Williams | Zendy; Kenneth R. Dardick | Zendy; Peter J. Krause | Zendy; Christina Brandeburg | Zendy; Christopher D. Crowder | Zendy; Heather E. Carolan | Zendy; Mark W. Eshoo | Zendy; Pamela A. Shaw | Zendy; Linden T. Hu | Zendy

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Xenodiagnosis to Detect Borrelia burgdorferi Infection: A First-in-Human Study

Author(s) -

Adriana Marques,

Sam R. Telford,

Siu-Ping Turk,

Erin Chung,

Carla Williams,

Kenneth R. Dardick,

Peter J. Krause,

Christina Brandeburg,

Christopher D. Crowder,

Heather E. Carolan,

Mark W. Eshoo,

Pamela A. Shaw,

Linden T. Hu

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit939

Subject(s) - xenodiagnosis , ixodes scapularis , borrelia burgdorferi , lyme disease , tick , medicine , erythema migrans , erythema chronicum migrans , ixodes , adverse effect , virology , immunology , microbiology and biotechnology , biology , antibody , trypanosoma cruzi , parasite hosting , lyme borreliosis , world wide web , computer science

Animal studies suggest that Borrelia burgdorferi, the agent of Lyme disease, may persist after antibiotic therapy and can be detected by various means including xenodiagnosis using the natural tick vector (Ixodes scapularis). No convincing evidence exists for the persistence of viable spirochetes after recommended courses of antibiotic therapy in humans. We determined the safety of using I. scapularis larvae for the xenodiagnosis of B. burgdorferi infection in humans.

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