High Rate of HIV Resuppression After Viral Failure on First-line Antiretroviral Therapy in the Absence of Switch to Second-line Therapy | Zendy

Ravindra K. Gupta | Zendy; Ruth Goodall | Zendy; Michael Rañopa | Zendy; Cissy Kityo | Zendy; Paula Munderi | Zendy; Fred Lyagoba | Zendy; Lincoln Mugarura | Zendy; Charles F. Gilks | Zendy; Pontiano Kaleebu | Zendy; Deenan Pillay | Zendy; Heiner Grosskurth | Zendy; Geoffrey Kabuye | Zendy; D. Nsibambi | Zendy; Ronnie Kasirye | Zendy; E. Zalwango | Zendy; M. Nakazibwe | Zendy; Bernard Kikaire | Zendy; G. Nassuna | Zendy; R. Massa | Zendy; K. Fadhiru | Zendy; M. Namyalo | Zendy; Aisha Zalwango | Zendy; L. Generous | Zendy; P. Khauka | Zendy; N. Rutikarayo | Zendy; W. Nakahima | Zendy; Apollo Mugisha | Zendy; Jim Todd | Zendy; Jonathan Levin | Zendy; Sylvia Kiwuwa Muyingo | Zendy; Anthony Ruberantwari | Zendy; David Yirrell | Zendy; N. Ndembi | Zendy; Peter J. Hughes | Zendy; M. Aber | Zendy; A. Medina Lara | Zendy; Scott A. Foster | Zendy; Jovita Amurwon | Zendy; Peter Mugyenyi | Zendy; Francis Ssali | Zendy; D. Tumukunde | Zendy; T. Otim | Zendy; Joseph Kabanda | Zendy; Hellen Musana | Zendy; Juliet Akao | Zendy; Hope Kyomugisha | Zendy; Adolf Byamukama | Zendy; J. Sabiiti | Zendy; J. Komugyena | Zendy; Priscilla Wavamunno | Zendy; S. Mukiibi | Zendy; Amos Drasiku | Zendy; R Byaruhanga | Zendy; O. Labeja | Zendy; Pauline Katundu | Zendy; S. Tugume | Zendy; P. Awio | Zendy; A. Namazzi | Zendy; T. G. Bakeinyaga | Zendy; H. Katabira | Zendy; D. Abaine | Zendy; J Tukamushaba | Zendy; W. Anywar | Zendy; W. Ojiambo | Zendy; E. Angweng | Zendy; Susan Murungi | Zendy; W. Haguma | Zendy; S. Atwiine | Zendy; Joanita Kigozi | Zendy; Ahmed Latif | Zendy; James Hakim | Zendy; Val J. Robertson | Zendy; Andrew Reid | Zendy; Ennie Chidziva | Zendy; R. Bulaya-Tembo | Zendy; Godfrey Musoro | Zendy; Fabian Taziwa | Zendy; Cleophas Chimbetete | Zendy; L. Chakonza | Zendy; A. Mawora | Zendy; C. Muvirimi | Zendy; G Tinago | Zendy; P. Svovanapasis | Zendy; M. Simango | Zendy; O. Chirema | Zendy; J. Machingura | Zendy; S Mutsai | Zendy; Mwelwa Phiri | Zendy; T Bafana | Zendy; M. Chirara | Zendy; Lazarus Muchabaiwa | Zendy; M. Muzambi | Zendy; Elly Katabira | Zendy; Allan Ronald | Zendy; A. Kambungu | Zendy; Fred Lutwama | Zendy; A. Nanfuka | Zendy; J Walusimbi | Zendy; Evelyn Nabankema | Zendy; R. Nalumenya | Zendy; T. Namuli | Zendy; R. Kulume | Zendy; I. Namata | Zendy; L. Nyachwo | Zendy; A. Florence | Zendy; A. Kusiima | Zendy; E Lubwama | Zendy; R. Nairuba | Zendy; F. Oketta | Zendy; E Buluma | Zendy; R. Waita | Zendy; Henry Ojiambo | Zendy; F. Sadik | Zendy; J Wanyama | Zendy; P. Nabongo | Zendy; Robert Ochai | Zendy; D. Muhweezi | Zendy; K. Boocock | Zendy; C. Puddephatt | Zendy; D. Winogron | Zendy; J. Kyle Bohan | Zendy; J. Darbyshire | Zendy; M. D. Gibb | Zendy; Andy Burke | Zendy; D. Bray | Zendy; AG Babiker | Zendy; Sarah Walker | Zendy; H Wilkes | Zendy; Mary Rauchenberger | Zendy; S. Sheehan | Zendy; Leon Peto | Zendy; Kirk A. Taylor | Zendy; Moira J. Spyer | Zendy; Alexander Ferrier | Zendy; B. Naidoo | Zendy; David Dunn | Zendy; R. Nanfuka | Zendy; C. Mufuka-Kapuya | Zendy; Anne Kapaata | Zendy; M. Katuramur | Zendy; Rose Magala | Zendy; Brian Magambo | Zendy; K. Mataruka | Zendy; Adele McCormick | Zendy; T. Musunga | Zendy; M. Nabankkema | Zendy; Jonathan Nkalubo | Zendy; Peter Nkurunziza | Zendy; Chris M. Parry | Zendy; B. Nyanzi Wakholi | Zendy; Ian Weller | Zendy; Silver Bahendeka | Zendy; Mary T. Bassett | Zendy; A. Chogo Wapakhabulo | Zendy; B Gazzard | Zendy; C. Mapuchere | Zendy; Owen Mugurungi | Zendy; Corey Burke | Zendy; Samuel Adeniyi Jones | Zendy; C.J. Newland | Zendy; S Rahim | Zendy; James F. Rooney | Zendy; M. Kumi Smith | Zendy; Wendy Snowden | Zendy; J.-M. Steens | Zendy; AM Breckenridge | Zendy; Anya T. McLaren | Zendy; C. Hill | Zendy; Jonathan Matenga | Zendy; Anton Pozniak | Zendy; David Serwadda | Zendy; Tim Peto | Zendy; Adrian Palfreeman | Zendy; Margaret Borok | Zendy

Open Access

High Rate of HIV Resuppression After Viral Failure on First-line Antiretroviral Therapy in the Absence of Switch to Second-line Therapy

Author(s) -

Ravindra K. Gupta,

Ruth Goodall,

Michael Rañopa,

Cissy Kityo,

Paula Munderi,

Fred Lyagoba,

Lincoln Mugarura,

Charles F. Gilks,

Pontiano Kaleebu,

Deenan Pillay,

Heiner Grosskurth,

Geoffrey Kabuye,

D. Nsibambi,

Ronnie Kasirye,

E. Zalwango,

M. Nakazibwe,

Bernard Kikaire,

G. Nassuna,

R. Massa,

K. Fadhiru,

M. Namyalo,

Aisha Zalwango,

L. Generous,

P. Khauka,

N. Rutikarayo,

W. Nakahima,

Apollo Mugisha,

Jim Todd,

Jonathan Levin,

Sylvia Kiwuwa Muyingo,

Anthony Ruberantwari,

David Yirrell,

N. Ndembi,

Peter J. Hughes,

M. Aber,

A. Medina Lara,

Scott A. Foster,

Jovita Amurwon,

Peter Mugyenyi,

Francis Ssali,

D. Tumukunde,

T. Otim,

Joseph Kabanda,

Hellen Musana,

Juliet Akao,

Hope Kyomugisha,

Adolf Byamukama,

J. Sabiiti,

J. Komugyena,

Priscilla Wavamunno,

S. Mukiibi,

Amos Drasiku,

R Byaruhanga,

O. Labeja,

Pauline Katundu,

S. Tugume,

P. Awio,

A. Namazzi,

T. G. Bakeinyaga,

H. Katabira,

D. Abaine,

J Tukamushaba,

W. Anywar,

W. Ojiambo,

E. Angweng,

Susan Murungi,

W. Haguma,

S. Atwiine,

Joanita Kigozi,

Ahmed Latif,

James Hakim,

Val J. Robertson,

Andrew Reid,

Ennie Chidziva,

R. Bulaya-Tembo,

Godfrey Musoro,

Fabian Taziwa,

Cleophas Chimbetete,

L. Chakonza,

A. Mawora,

C. Muvirimi,

G Tinago,

P. Svovanapasis,

M. Simango,

O. Chirema,

J. Machingura,

S Mutsai,

Mwelwa Phiri,

T Bafana,

M. Chirara,

Lazarus Muchabaiwa,

M. Muzambi,

Elly Katabira,

Allan Ronald,

A. Kambungu,

Fred Lutwama,

A. Nanfuka,

J Walusimbi,

Evelyn Nabankema,

R. Nalumenya,

T. Namuli,

R. Kulume,

I. Namata,

L. Nyachwo,

A. Florence,

A. Kusiima,

E Lubwama,

R. Nairuba,

F. Oketta,

E Buluma,

R. Waita,

Henry Ojiambo,

F. Sadik,

J Wanyama,

P. Nabongo,

Robert Ochai,

D. Muhweezi,

K. Boocock,

C. Puddephatt,

D. Winogron,

J. Kyle Bohan,

J. Darbyshire,

M. D. Gibb,

Andy Burke,

D. Bray,

AG Babiker,

Sarah Walker,

H Wilkes,

Mary Rauchenberger,

S. Sheehan,

Leon Peto,

Kirk A. Taylor,

Moira J. Spyer,

Alexander Ferrier,

B. Naidoo,

David Dunn,

R. Nanfuka,

C. Mufuka-Kapuya,

Anne Kapaata,

M. Katuramur,

Rose Magala,

Brian Magambo,

K. Mataruka,

Adele McCormick,

T. Musunga,

M. Nabankkema,

Jonathan Nkalubo,

Peter Nkurunziza,

Chris M. Parry,

B. Nyanzi Wakholi,

Ian Weller,

Silver Bahendeka,

Mary T. Bassett,

A. Chogo Wapakhabulo,

B Gazzard,

C. Mapuchere,

Owen Mugurungi,

Corey Burke,

Samuel Adeniyi Jones,

C.J. Newland,

S Rahim,

James F. Rooney,

M. Kumi Smith,

Wendy Snowden,

J.-M. Steens,

AM Breckenridge,

Anya T. McLaren,

C. Hill,

Jonathan Matenga,

Anton Pozniak,

David Serwadda,

Tim Peto,

Adrian Palfreeman,

Margaret Borok

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit933

Subject(s) - medicine , zidovudine , nevirapine , lamivudine , abacavir , viral load , antiretroviral therapy , second line therapy , human immunodeficiency virus (hiv) , tenofovir , virology , viral disease , chemotherapy , virus , hepatitis b virus

In a randomized comparison of nevirapine or abacavir with zidovudine plus lamivudine, routine viral load monitoring was not performed, yet 27% of individuals with viral failure at week 48 experienced resuppression by week 96 without switching. This supports World Health Organization recommendations that suspected viral failure should trigger adherence counseling and repeat measurement before a treatment switch is considered.

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