A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy | Zendy

Adam M. Spivak | Zendy; Adriana Andrade | Zendy; Evelyn E. Eisele | Zendy; Rebecca Hoh | Zendy; Peter Bacchetti | Zendy; Namandjé N. Bumpus | Zendy; Fatemeh Emad | Zendy; Robert W. Buckheit | Zendy; Elinore F. McCanceKatz | Zendy; J. C. K. Lai | Zendy; Esther M. John | Zendy; Geetanjali Chander | Zendy; Robert F. Siliciano | Zendy; J. D. Siliciano | Zendy; Steven G. Deeks | Zendy

Open Access

A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy

Author(s) -

Adam M. Spivak,

Adriana Andrade,

Evelyn E. Eisele,

Rebecca Hoh,

Peter Bacchetti,

Namandjé N. Bumpus,

Fatemeh Emad,

Robert W. Buckheit,

Elinore F. McCanceKatz,

J. C. K. Lai,

Esther M. John,

Geetanjali Chander,

Robert F. Siliciano,

J. D. Siliciano,

Steven G. Deeks

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit813

Subject(s) - viremia , disulfiram , medicine , immunology , viral load , pharmacology , confidence interval , reverse transcriptase inhibitor , antiretroviral therapy , virology , human immunodeficiency virus (hiv)

Transcriptionally silent human immunodeficiency virus type 1 (HIV-1) DNA persists in resting memory CD4(+) T cells despite antiretroviral therapy. In a primary cell model, the antialcoholism drug disulfiram has been shown to induce HIV-1 transcription in latently infected resting memory CD4(+) T cells at concentrations achieved in vivo.

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