High Prevalence of Antibiotic-Resistant Mycoplasma genitalium in Nongonococcal Urethritis: The Need for Routine Testing and the Inadequacy of Current Treatment Options | Zendy

Marcus Pond | Zendy; Achyuta Nori | Zendy; Adam A. Witney | Zendy; Rose C. Lopeman | Zendy; Philip D. Butcher | Zendy; S Tariq Sadiq | Zendy

Open Access

High Prevalence of Antibiotic-Resistant Mycoplasma genitalium in Nongonococcal Urethritis: The Need for Routine Testing and the Inadequacy of Current Treatment Options

Author(s) -

Marcus Pond,

Achyuta Nori,

Adam A. Witney,

Rose C. Lopeman,

Philip D. Butcher,

S Tariq Sadiq

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit752

Subject(s) - mycoplasma genitalium , urethritis , chlamydia trachomatis , medicine , cervicitis , non gonococcal urethritis , doxycycline , chlamydia , empirical treatment , mycoplasma , antibiotics , antibiotic resistance , azithromycin , microbiology and biotechnology , gynecology , immunology , biology

Empirical antibiotic therapy for nongonococcal urethritis (NGU) and cervicitis is aimed at Chlamydia trachomatis, but Mycoplasma genitalium, which also commonly causes undiagnosed NGU, necessitates treatment with macrolides or fluoroquinolones rather than doxycycline, the preferred chlamydia treatment. Prevalence of M. genitalium and associated genotypic markers of macrolide and fluoroquinolone resistance among men symptomatic of urethritis were investigated. Genetic diversity of M. genitalium populations was determined to infer whether findings were applicable beyond our setting.

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