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Escherichia coli Dysbiosis Correlates With Gastrointestinal Dysfunction in Children With Cystic Fibrosis
Author(s) -
Lucas R. Hoffman,
Christopher E. Pope,
Hillary S. Hayden,
Sonya L. Heltshe,
Roie Levy,
Sharon McNamara,
Michael A. Jacobs,
Laurence Rohmer,
Matthew C. Radey,
Bonnie W. Ramsey,
M. Brittnacher,
Elhanan Borenstein,
Samuel I. Miller
Publication year - 2013
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/cit715
Subject(s) - cystic fibrosis , malabsorption , dysbiosis , medicine , feces , inflammation , gastroenterology , escherichia coli , fibrosis , gastrointestinal tract , immunology , disease , microbiology and biotechnology , biology , biochemistry , gene
Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.

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