Priapism Induced by Boceprevir-CYP3A4 Inhibition and -Adrenergic Blockade: Case Report | Zendy

Kyle P. Hammond | Zendy; Christen B. Nielsen | Zendy; Sunny A. Linnebur | Zendy; Jacob Langness | Zendy; G. Thomas Ray | Zendy; Paul Maroni | Zendy; Jennifer J. Kiser | Zendy

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Priapism Induced by Boceprevir-CYP3A4 Inhibition and -Adrenergic Blockade: Case Report

Author(s) -

Kyle P. Hammond,

Christen B. Nielsen,

Sunny A. Linnebur,

Jacob Langness,

G. Thomas Ray,

Paul Maroni,

Jennifer J. Kiser

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit673

Subject(s) - medicine , priapism , blockade , cyp3a4 , granisetron , pharmacology , doxazosin , tamsulosin , anesthesia , surgery , chemotherapy , receptor , cytochrome p450 , metabolism , blood pressure , hyperplasia , antiemetic

A 44-year-old white man presented to the emergency department with a 3-day history of priapism requiring a surgically performed distal penile shunt. A drug-drug interaction is the suspected cause whereby CYP3A4 inhibition by boceprevir led to increased exposures of doxazosin, tamsulosin, and/or quetiapine, resulting in additional α-adrenergic blockade.

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