Breadth of Anti-Merozoite Antibody Responses Is Associated With the Genetic Diversity of Asymptomatic Plasmodium falciparum Infections and Protection Against Clinical Malaria | Zendy

Josea Rono | Zendy; Faith Osier | Zendy; Daniel Olsson | Zendy; Scott Montgomery | Zendy; Leah Mhoja | Zendy; Ingegerd Rooth | Zendy; Kevin Marsh | Zendy; Anna Färnert | Zendy

Open Access

Breadth of Anti-Merozoite Antibody Responses Is Associated With the Genetic Diversity of Asymptomatic Plasmodium falciparum Infections and Protection Against Clinical Malaria

Author(s) -

Josea Rono,

Faith Osier,

Daniel Olsson,

Scott Montgomery,

Leah Mhoja,

Ingegerd Rooth,

Kevin Marsh,

Anna Färnert

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit556

Subject(s) - malaria , plasmodium falciparum , medicine , immunology , asymptomatic , antibody , genetic diversity , virology , apicomplexa , population , environmental health , pathology

Elucidating the mechanisms of naturally acquired immunity to Plasmodium falciparum infections would be highly valuable for malaria vaccine development. Asymptomatic multiclonal infections have been shown to predict protection from clinical malaria in a transmission-dependent manner, but the mechanisms underlying this are unclear. We assessed the breadth of antibody responses to several vaccine candidate merozoite antigens in relation to the infecting parasite population and clinical immunity.

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