Evaluation of Hepatitis C Virus as a Risk Factor for HIV-Associated Neuroretinal Disorder | Zendy

Andrea D. Branch | Zendy; Lea T. Drye | Zendy; Mark L. Van Natta | Zendy; Efe Sezgın | Zendy; Sarah L. Fishman | Zendy; Douglas T. Dieterich | Zendy; Curtis L. Meinert | Zendy; Douglas A. Jabs | Zendy

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Evaluation of Hepatitis C Virus as a Risk Factor for HIV-Associated Neuroretinal Disorder

Author(s) -

Andrea D. Branch,

Lea T. Drye,

Mark L. Van Natta,

Efe Sezgın,

Sarah L. Fishman,

Douglas T. Dieterich,

Curtis L. Meinert,

Douglas A. Jabs

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit550

Subject(s) - medicine , hepatitis c virus , single nucleotide polymorphism , virus , virology , immunology , hepatitis c , human immunodeficiency virus (hiv) , cytokine , genotype , gene , genetics , biology

Both hepatitis C virus (HCV) and human immunodeficiency virus (HIV) penetrate the central nervous system. HIV-associated neuroretinal disorder (HIV-NRD), a visual impairment of reduced contrast sensitivity and reading ability, is associated with cytokine dysregulation and genetic polymorphisms in the anti-inflammatory interleukin 10 (IL-10) signaling pathway. We investigated associations between HCV and HIV-NRD and between HCV and single-nucleotide polymorphisms (SNPs) in the IL-10 receptor 1 (IL10R1) gene.

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