A Randomized Controlled Pilot Trial of Valacyclovir for Attenuating Inflammation and Immune Activation in HIV/Herpes Simplex Virus 2–Coinfected Adults on Suppressive Antiretroviral Therapy | Zendy

Tae Joon Yi | Zendy; Sharon Walmsley | Zendy; Leah Szadkowski | Zendy; Janet Raboud | Zendy; Nimerta Rajwans | Zendy; Brett Shan | Zendy; Sachin Kumar | Zendy; Kevin C. Kain | Zendy; Rupert Kaul | Zendy; Darrell H. S. Tan | Zendy

Open Access

A Randomized Controlled Pilot Trial of Valacyclovir for Attenuating Inflammation and Immune Activation in HIV/Herpes Simplex Virus 2–Coinfected Adults on Suppressive Antiretroviral Therapy

Author(s) -

Tae Joon Yi,

Sharon Walmsley,

Leah Szadkowski,

Janet Raboud,

Nimerta Rajwans,

Brett Shan,

Sachin Kumar,

Kevin C. Kain,

Rupert Kaul,

Darrell H. S. Tan

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit539

Subject(s) - medicine , coinfection , herpes simplex virus , inflammation , immunology , immune system , virology , virus , human immunodeficiency virus (hiv) , immunopathology

Human immunodeficiency virus (HIV) is associated with increased systemic inflammation and immune activation that persist despite suppressive antiretroviral therapy (ART). Herpes simplex virus type 2 (HSV-2) is a common coinfection that may contribute to this inflammation.

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