Impact of MALDI-TOF Will Be Highly Dependent on the Clinician

TO THE EDITOR—Clerc et al recently reported a real-life use of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF) to optimize the choice of antibiotherapy for bloodstream infections [1]. The advent of MALDI-TOF triggered numerous articles and great hopes about how it would change the organization of microbiology laboratories. However, little is known about its impact on infectious diseases (ID) specialists’ clinical practice or on antimicrobial stewardship. Therefore, we acknowledge and congratulate the authors for being one of the few groups of investigators to study the impact of MALDITOF on clinical practice. However, the authors chose to focus on gram-negative bacteria because MALDITOF is less reliable for gram-positive