High-Dose Intravenous Methylprednisolone for Hantavirus Cardiopulmonary Syndrome in Chile: A Double-Blind, Randomized Controlled Clinical Trial | Zendy

Pablo Vial | Zendy; Francisca Valdivieso | Zendy; Marcela Ferrés | Zendy; Raúl Riquelme | Zendy; María Luisa Rioseco | Zendy; Mario Calvo | Zendy; Constanza Castillo | Zendy; Ricardo Sobhie Diaz | Zendy; Luis Scholz | Zendy; Analía Cuiza | Zendy; Edith Belmar | Zendy; Carla Hernandez | Zendy; Jessica Martínez | Zendy; Sang-Joon Lee | Zendy; Grégory Mertz | Zendy; Juan Abarca | Zendy; Vinko Tomicić | Zendy; M. Eugenia Aracena | Zendy; Ana Maria Rehbein | Zendy; Soledad Velásquez | Zendy; Victoria Lavin | Zendy; Felipe Garrido | Zendy; Pere Godoy | Zendy; Constanza Martinez | Zendy; Juan Carlos Chamorro | Zendy; Jorge Contreras | Zendy; Jury Hernandez | Zendy; Marcelo Pino | Zendy; Paola Villegas | Zendy; Viviana Marcela Arias Zapata | Zendy; Marisol León | Zendy; Ivonne Vega | Zendy; Irisol Otarola | Zendy; Carlos Ortega | Zendy; Elizabeth Daube | Zendy; Doris Huecha | Zendy; Alda Neira | Zendy; I.Davila Ruiz | Zendy; Margarita Nunez | Zendy; Luz Monsalve | Zendy; Henriette Chabouty | Zendy; L. Zamorano Riquelme | Zendy; Samia Palma | Zendy; Raúl Bustos | Zendy; R.Infante Miranda | Zendy; Jovita Mardones | Zendy; Nora Hernández | Zendy; Yasna Betancur | Zendy; L. Elso Sanhueza | Zendy; Jaime Inostroza | Zendy; S Donoso | Zendy; Maritza Navarrete | Zendy; Lily Acuña | Zendy; Paulina Manriquez | Zendy; Fabiola Castillo | Zendy; Paola Unzueta | Zendy; Teresa Aguilera | Zendy; Carola Osorio | Zendy; Veronica Yobanolo | Zendy; J Mardones | Zendy; Sandra Aranda | Zendy; Soledad Carvajal | Zendy; Moisés H. Sandoval | Zendy; Soraya Daza | Zendy; Felipe Vargas | Zendy; Violeta Díaz | Zendy; Mauricio Riquelme | Zendy; Miriam Galián Muñoz | Zendy; Andrea Carriel | Zendy; Paola Lanino | Zendy; Susana A. Hernandez | Zendy; Patricia W. Schumacher | Zendy; Lia Yañez | Zendy; Claudia Marco | Zendy; M Ehrenfeld | Zendy; Iris Delgado | Zendy; Susana P. Mejía | Zendy; Cecilia Vial | Zendy; Edward J. Bedrick | Zendy

Open Access

High-Dose Intravenous Methylprednisolone for Hantavirus Cardiopulmonary Syndrome in Chile: A Double-Blind, Randomized Controlled Clinical Trial

Author(s) -

Pablo Vial,

Francisca Valdivieso,

Marcela Ferrés,

Raúl Riquelme,

María Luisa Rioseco,

Mario Calvo,

Constanza Castillo,

Ricardo Sobhie Diaz,

Luis Scholz,

Analía Cuiza,

Edith Belmar,

Carla Hernandez,

Jessica Martínez,

Sang-Joon Lee,

Grégory Mertz,

Juan Abarca,

Vinko Tomicić,

M. Eugenia Aracena,

Ana Maria Rehbein,

Soledad Velásquez,

Victoria Lavin,

Felipe Garrido,

Pere Godoy,

Constanza Martinez,

Juan Carlos Chamorro,

Jorge Contreras,

Jury Hernandez,

Marcelo Pino,

Paola Villegas,

Viviana Marcela Arias Zapata,

Marisol León,

Ivonne Vega,

Irisol Otarola,

Carlos Ortega,

Elizabeth Daube,

Doris Huecha,

Alda Neira,

I.Davila Ruiz,

Margarita Nunez,

Luz Monsalve,

Henriette Chabouty,

L. Zamorano Riquelme,

Samia Palma,

Raúl Bustos,

R.Infante Miranda,

Jovita Mardones,

Nora Hernández,

Yasna Betancur,

L. Elso Sanhueza,

Jaime Inostroza,

S Donoso,

Maritza Navarrete,

Lily Acuña,

Paulina Manriquez,

Fabiola Castillo,

Paola Unzueta,

Teresa Aguilera,

Carola Osorio,

Veronica Yobanolo,

J Mardones,

Sandra Aranda,

Soledad Carvajal,

Moisés H. Sandoval,

Soraya Daza,

Felipe Vargas,

Violeta Díaz,

Mauricio Riquelme,

Miriam Galián Muñoz,

Andrea Carriel,

Paola Lanino,

Susana A. Hernandez,

Patricia W. Schumacher,

Lia Yañez,

Claudia Marco,

M Ehrenfeld,

Iris Delgado,

Susana P. Mejía,

Cecilia Vial,

Edward J. Bedrick

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit394

Subject(s) - medicine , methylprednisolone , placebo , adverse effect , clinical endpoint , anesthesia , randomized controlled trial , surgery , pathology , alternative medicine

Andes virus (ANDV)-related hantavirus cardiopulmonary syndrome (HCPS) has a 35% case fatality rate in Chile and no specific treatment. In an immunomodulatory approach, we evaluated the efficacy of intravenous methylprednisolone for HCPS treatment, through a parallel-group, placebo-controlled clinical trial.

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