Characterizing Vaccine Responses Using Host Genomic and Transcriptomic Analysis | Zendy

Daniel O’Connor | Zendy; Andrew J. Pollard | Zendy

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Characterizing Vaccine Responses Using Host Genomic and Transcriptomic Analysis

Author(s) -

Daniel O’Connor,

Andrew J. Pollard

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit373

Subject(s) - immunity , medicine , transcriptome , genome , disease , immunology , computational biology , infectious disease (medical specialty) , vaccine efficacy , genomics , immune system , virology , bioinformatics , biology , genetics , gene , gene expression , pathology

Vaccines have had a profound influence on human health with no other health intervention rivaling their impact on the morbidity and mortality associated with infectious disease. However, the magnitude and persistence of vaccine immunity varies considerably between individuals, a phenomenon that is not well understood. Recent studies have used contemporary technologies to correlate variation in the genome and transcriptome to immunological measures of vaccine responsiveness. These approaches have provided fresh insight into the intrinsic factors determining the potency and duration of vaccine-induced immunity. The fundamental challenge will be to translate these findings into innovative and pragmatic strategies to develop new and more effective vaccines.

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