A Single Amino-Acid Change in a Highly Conserved Motif of gp41 Elicits HIV-1 Neutralization and Protects Against CD4 Depletion | Zendy

Caroline Petitdemange | Zendy; Abla Achour | Zendy; Stefania Dispinseri | Zendy; Isabelle Malet | Zendy; Alexis Sennepin | Zendy; Raphaël Ho Tsong Fang | Zendy; Joël Crouzet | Zendy; AnneGeneviève Marcelin | Zendy; Vincent Cálvez | Zendy; Gabriella Scarlatti | Zendy; Patrice Debré | Zendy; Vincent Vieillard | Zendy

Open Access

A Single Amino-Acid Change in a Highly Conserved Motif of gp41 Elicits HIV-1 Neutralization and Protects Against CD4 Depletion

Author(s) -

Caroline Petitdemange,

Abla Achour,

Stefania Dispinseri,

Isabelle Malet,

Alexis Sennepin,

Raphaël Ho Tsong Fang,

Joël Crouzet,

AnneGeneviève Marcelin,

Vincent Cálvez,

Gabriella Scarlatti,

Patrice Debré,

Vincent Vieillard

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit335

Subject(s) - neutralization , human immunodeficiency virus (hiv) , gp41 , medicine , motif (music) , virology , structural motif , genetics , microbiology and biotechnology , immunology , virus , biology , biochemistry , antibody , epitope , physics , acoustics

The induction of neutralizing antibodies against conserved regions of the human immunodeficiency virus type 1 (HIV-1) envelope protein is a major goal of vaccine strategies. We previously identified 3S, a critical conserved motif of gp41 that induces the NKp44L ligand of an activating NK receptor. In vivo, anti-3S antibodies protect against the natural killer (NK) cell-mediated CD4 depletion that occurs without efficient viral neutralization.

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