Reply to Gelfand et al and Solla

TO THE EDITOR—We appreciate the interest Gelfand et al [1] have shown regarding our observational, nonrandomized, comparative multicenter study [2]. Infective endocarditis (IE) is an uncommon, severe disease [3], and it is inevitable that randomized trials on this condition are lacking. In our observational study, the combination of ampicillin and ceftriaxone (AC) was compared with the standard-of-care ampicillin and gentamicin combination (AG) for treating Enterococcus faecalis IE, but other comparisons