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In late 2011 and early 2012, 13 cases of human influenza resulted from infection with a novel triple reassortant swine-origin influenza virus, influenza A (H3N2) variant. This variant was notable for its inclusion of the matrix gene from the 2009 influenza A(H1N1) pandemic virus. While most of these confirmed cases were among children, the transmission potential and likely age-dependent susceptibility to the virus was unknown. Preliminary serologic studies indicated that very young children have less protection than older children and adults.

Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v)