Next-Generation Whole Genome Sequencing Identifies the Direction of Norovirus Transmission in Linked Patients | Zendy

Samit Kundu | Zendy; Julianne Lockwood | Zendy; Daniel P. Depledge | Zendy; Yasmin Chaudhry | Zendy; Antony Aston | Zendy; Kanchan Rao | Zendy; John C. Hartley | Zendy; Ian Goodfellow | Zendy; Judith Breuer | Zendy

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Next-Generation Whole Genome Sequencing Identifies the Direction of Norovirus Transmission in Linked Patients

Author(s) -

Samit Kundu,

Julianne Lockwood,

Daniel P. Depledge,

Yasmin Chaudhry,

Antony Aston,

Kanchan Rao,

John C. Hartley,

Ian Goodfellow,

Judith Breuer

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit287

Subject(s) - norovirus , amplicon , genome , phylogenetic tree , outbreak , virology , transmission (telecommunications) , whole genome sequencing , dna sequencing , polymerase chain reaction , biology , medicine , infection control , genetics , dna , gene , electrical engineering , engineering , pathology

Noroviruses are a highly transmissible and major cause of nosocomial gastroenteritis resulting in bed and hospital-ward closures. Where hospital outbreaks are suspected, it is important to determine the routes of spread so that appropriate infection-control procedures can be implemented. To investigate a cluster of norovirus cases occurring in children undergoing bone marrow transplant, we undertook norovirus genome sequencing by next-generation methods. Detailed comparison of sequence data from 2 linked cases enabled us to identify the likely direction of spread.

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