Colistin and Rifampicin Compared With Colistin Alone for the Treatment of Serious Infections Due to Extensively Drug-Resistant Acinetobacter baumannii: A Multicenter, Randomized Clinical Trial | Zendy

Emanuele DuranteMangoni | Zendy; Giuseppe Signoriello | Zendy; Roberto Andini | Zendy; A. Mattei | Zendy; Maria De Cristoforo | Zendy; Patrizia Murino | Zendy; Matteo Bassetti | Zendy; P Malacarne | Zendy; Nicola Petrosillo | Zendy; Nicola Galdieri | Zendy; Paola Elvira Mocavero | Zendy; Antonio Corcione | Zendy; Claudio Viscoli | Zendy; Raffaele Zarrilli | Zendy; Ciro Gallo | Zendy; Riccardo Utili | Zendy

Open Access

Colistin and Rifampicin Compared With Colistin Alone for the Treatment of Serious Infections Due to Extensively Drug-Resistant Acinetobacter baumannii: A Multicenter, Randomized Clinical Trial

Author(s) -

Emanuele DuranteMangoni,

Giuseppe Signoriello,

Roberto Andini,

A. Mattei,

Maria De Cristoforo,

Patrizia Murino,

Matteo Bassetti,

P Malacarne,

Nicola Petrosillo,

Nicola Galdieri,

Paola Elvira Mocavero,

Antonio Corcione,

Claudio Viscoli,

Raffaele Zarrilli,

Ciro Gallo,

Riccardo Utili

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit253

Subject(s) - colistin , acinetobacter baumannii , medicine , rifampicin , drug , antibiotics , drug resistance , clinical trial , intensive care medicine , pharmacology , microbiology and biotechnology , bacteria , pseudomonas aeruginosa , biology , tuberculosis , pathology , genetics

Extensively drug-resistant (XDR) Acinetobacter baumannii may cause serious infections in critically ill patients. Colistin often remains the only therapeutic option. Addition of rifampicin to colistin may be synergistic in vitro. In this study, we assessed whether the combination of colistin and rifampicin reduced the mortality of XDR A. baumannii infections compared to colistin alone.

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