Markers of Intestinal Inflammation, Not Bacterial Burden, Correlate With Clinical Outcomes in Clostridium difficile Infection | Zendy

Rana E. El Feghaly | Zendy; Jennifer L. Stauber | Zendy; Elena Deych | Zendy; Carlos G. Gonzalez | Zendy; Phillip I. Tarr | Zendy; David Haslam | Zendy

Open Access

Markers of Intestinal Inflammation, Not Bacterial Burden, Correlate With Clinical Outcomes in Clostridium difficile Infection

Author(s) -

Rana E. El Feghaly,

Jennifer L. Stauber,

Elena Deych,

Carlos G. Gonzalez,

Phillip I. Tarr,

David Haslam

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit147

Subject(s) - medicine , clostridium difficile , metronidazole , diarrhea , feces , vancomycin , immunology , antibiotics , gastroenterology , prospective cohort study , microbiology and biotechnology , biology , staphylococcus aureus , genetics , bacteria

Clostridium difficile is a leading hospital-acquired infection. Many patients remain symptomatic for several days on appropriate antibiotic therapy. To assess the contribution of ongoing infection vs persistent inflammation, we examined the correlation between fecal cytokine levels, fecal C. difficile burden, and disease outcomes in C. difficile infection (CDI).

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