Use of Cellular HIV DNA to Predict Virologic Response to Maraviroc: Performance of Population-Based and Deep Sequencing | Zendy

Luke C. Swenson | Zendy; Winnie Dong | Zendy; Theresa Mo | Zendy; James F. Demarest | Zendy; Doug Chapman | Zendy; Suzanne S. Ellery | Zendy; Jayvant Heera | Zendy; Hernán Valdez | Zendy; Art F. Y. Poon | Zendy; P. Richard Harrigan | Zendy

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Use of Cellular HIV DNA to Predict Virologic Response to Maraviroc: Performance of Population-Based and Deep Sequencing

Author(s) -

Luke C. Swenson,

Winnie Dong,

Theresa Mo,

James F. Demarest,

Doug Chapman,

Suzanne S. Ellery,

Jayvant Heera,

Hernán Valdez,

Art F. Y. Poon,

P. Richard Harrigan

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit105

Subject(s) - maraviroc , ccr5 receptor antagonist , tropism , medicine , virology , peripheral blood mononuclear cell , viral load , tissue tropism , population , lentivirus , immunology , human immunodeficiency virus (hiv) , virus , viral disease , biology , inflammation , chemokine , in vitro , environmental health , chemokine receptor , biochemistry

A tropism test is required before administration of the antiretroviral drug maraviroc. However, plasma RNA testing is not possible in patients with undetectable plasma viral loads. Here we assess genotypic testing of cellular human immunodeficiency virus (HIV) DNA from peripheral blood mononuclear cells (PBMCs) to predict virologic responses in treatment-experienced patients beginning maraviroc-containing regimens.

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