Reduced Risk of Pertussis Among Persons Ever Vaccinated With Whole Cell Pertussis Vaccine Compared to Recipients of Acellular Pertussis Vaccines in a Large US Cohort | Zendy

M.A. Witt | Zendy; Larry Arias | Zendy; P. H. Katz | Zendy; Elizabeth T. Truong | Zendy; David Witt | Zendy

Open Access

Reduced Risk of Pertussis Among Persons Ever Vaccinated With Whole Cell Pertussis Vaccine Compared to Recipients of Acellular Pertussis Vaccines in a Large US Cohort

Author(s) -

M.A. Witt,

Larry Arias,

P. H. Katz,

Elizabeth T. Truong,

David Witt

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit046

Subject(s) - medicine , pertussis vaccine , vaccination , whooping cough , immunology , herd immunity , virology , outbreak , pediatrics , immunization , antibody

Unexpected waning of immunity after pertussis vaccination is now well described. In this study we examined whether prior vaccination with whole-cell pertussis vaccine (wP) at any point provided superior protection contrasted with a solely acellular pertussis vaccine (aP) series. We utilized the coincidence of a large outbreak of pertussis with the termination of wP availability, providing populations of children who had been vaccinated with combinations of wP and aP.

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