Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population | Zendy

Daniel F. Carr | Zendy; Mas Chaponda | Zendy; Andrea Jorgensen | Zendy; Elena Cornejo Castro | Zendy; Joep J. van Oosterhout | Zendy; Saye Khoo | Zendy; David G. Lalloo | Zendy; Robert S. Heyderman | Zendy; Ana Alfirevic | Zendy; Munir Pirmohamed | Zendy

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Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population

Author(s) -

Daniel F. Carr,

Mas Chaponda,

Andrea Jorgensen,

Elena Cornejo Castro,

Joep J. van Oosterhout,

Saye Khoo,

David G. Lalloo,

Robert S. Heyderman,

Ana Alfirevic,

Munir Pirmohamed

Publication year - 2013

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cit021

Subject(s) - nevirapine , medicine , odds ratio , toxic epidermal necrolysis , immunology , human leukocyte antigen , population , antigen , dermatology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , environmental health

The nonnucleoside reverse transcriptase inhibitor nevirapine is the cornerstone of treatment for human immunodeficiency virus (HIV) in many sub-Saharan African countries. However, nevirapine is associated with a 6%-10% risk of developing a hypersensitivity reaction, with different phenotypes, including the blistering conditions Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Our aim was to identify predictive human leukocyte antigen (HLA) markers that are associated with nevirapine hypersensitivity.

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