Patterns and Causes of Suboptimal Response to Tenofovir-Based Therapy in Individuals Coinfected With HIV and Hepatitis B Virus
Author(s) -
Gail Matthews,
Eric C. Seaberg,
Anchalee Avihingsa,
Scott Bowden,
Gregory J. Dore,
Sharon R. Lewin,
Joe Sasadeusz,
Peter Revill,
Margaret Littlejohn,
Jennifer Hoy,
Robert Finlayson,
Kiat Ruxrungtham,
Melissa Saulynas,
Stephen Locarnini,
Chloe L. Thio
Publication year - 2013
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/cit002
Subject(s) - medicine , tenofovir , human immunodeficiency virus (hiv) , virology , hepatitis b virus , antiretroviral therapy , hepatitis c virus , sida , virus , viral disease , viral load
Tenofovir (TDF) is effective for treatment of hepatitis B virus (HBV) in human immunodeficiency virus (HIV) infection; however, some individuals have ongoing HBV viremia, the reasons for which are unclear. We determined the patterns and factors associated with detectable HBV DNA in HIV-HBV-coinfected subjects on highly active antiretroviral therapy (HAART).
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