Assessment of Cytomegalovirus-Specific Cell-Mediated Immunity for the Prediction of Cytomegalovirus Disease in High-Risk Solid-Organ Transplant Recipients: A Multicenter Cohort Study
Author(s) -
Oriol Manuel,
Shahid Husain,
Dinesh Kumar,
Carlos Zayas,
S D Mawhorter,
Marilyn E. Levi,
Jayant Kalpoe,
Luiz F. Lisboa,
Leticia Ely,
Daniel Kaul,
Brian S. Schwartz,
Michele I. Morris,
Michael G. Ison,
Belinda YenLieberman,
A. Sébastian,
Maha Assi,
Atul Humar
Publication year - 2012
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/cis993
Subject(s) - medicine , cytomegalovirus , immunology , immunity , betaherpesvirinae , cytomegalovirus infection , disease , human cytomegalovirus , transplantation , solid organ , organ transplantation , cytomegalovirus infections , cohort , viral disease , herpesviridae , immune system , virus
Cytomegalovirus (CMV) disease remains an important problem in solid-organ transplant recipients, with the greatest risk among donor CMV-seropositive, recipient-seronegative (D(+)/R(-)) patients. CMV-specific cell-mediated immunity may be able to predict which patients will develop CMV disease.
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