Carbapenem-Sparing Antibiotic Regimens for Infections Caused by Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae in Intensive Care Unit | Zendy

Francesco Sbrana | Zendy; P Malacarne | Zendy; Bruno Viaggi | Zendy; S. Costanzo | Zendy; P Léonetti | Zendy; Alessandro Leonildi | Zendy; Beatrice Casini | Zendy; Carlo Tascini | Zendy; Francesco Menichetti | Zendy

Open Access

Carbapenem-Sparing Antibiotic Regimens for Infections Caused by Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae in Intensive Care Unit

Author(s) -

Francesco Sbrana,

P Malacarne,

Bruno Viaggi,

S. Costanzo,

P Léonetti,

Alessandro Leonildi,

Beatrice Casini,

Carlo Tascini,

Francesco Menichetti

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cis969

Subject(s) - medicine , klebsiella pneumoniae , tigecycline , colistin , carbapenem , intensive care unit , antibiotics , gentamicin , intensive care medicine , microbiology and biotechnology , biochemistry , escherichia coli , biology , gene , chemistry

A carbapenem-sparing regimen of tigecycline plus gentamicin or colistin was effective for treating 24 of 26 (92%) Klebsiella pneumoniae carbapenemase-producing K. pneumoniae infectious episodes in 22 polytrauma intensive care unit patients without comorbidities. The 30-day crude mortality rate was 14%. Regimens were considered appropriate in 12% of episodes according to the Vitek 2 System and in 100% based on E-test.

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