The Effect of Primaquine on Gametocyte Development and Clearance in the Treatment of Uncomplicated Falciparum Malaria With Dihydroartemisinin-Piperaquine in South Sumatra, Western Indonesia: An Open-Label, Randomized, Controlled Trial | Zendy

Inge Sutanto | Zendy; Sri Suprijanto | Zendy; Ayleen Kosasih | Zendy; M. Sopiyudin Dahlan | Zendy; Din Syafruddin | Zendy; Rita Kusriastuti | Zendy; Penelope A. Phillips–Howard | Zendy; Neil F. Lobo | Zendy; Feiko O. ter Kuile | Zendy

Open Access

The Effect of Primaquine on Gametocyte Development and Clearance in the Treatment of Uncomplicated Falciparum Malaria With Dihydroartemisinin-Piperaquine in South Sumatra, Western Indonesia: An Open-Label, Randomized, Controlled Trial

Author(s) -

Inge Sutanto,

Sri Suprijanto,

Ayleen Kosasih,

M. Sopiyudin Dahlan,

Din Syafruddin,

Rita Kusriastuti,

Penelope A. Phillips–Howard,

Neil F. Lobo,

Feiko O. ter Kuile

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cis959

Subject(s) - primaquine , gametocyte , malaria , artemisinin , piperaquine , dihydroartemisinin , medicine , plasmodium falciparum , pharmacology , immunology , chloroquine

Artemisinin-based combination therapy is very effective in clearing asexual stages of malaria and reduces gametocytemia, but may not affect mature gametocytes. Primaquine is the only commercially available drug that eliminates mature gametocytes.

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