Effect of High-Dose or Split-Dose Artesunate on Parasite Clearance in Artemisinin-Resistant Falciparum Malaria | Zendy

Debashish Das | Zendy; Rupam Tripura | Zendy; Aung Pyae Phyo | Zendy; Khin Maung Lwin | Zendy; Joel Tärning | Zendy; Sue J. Lee | Zendy; Warunee Hanpithakpong | Zendy; Kasia Stepniewska | Zendy; Didier Ménard | Zendy; Pascal Ringwald | Zendy; Kamolrat Silamut | Zendy; Mallika Imwong | Zendy; Kesinee Chotivanich | Zendy; Poravuth Yi | Zendy; Nicholas Day | Zendy; Niklas Lindegårdh | Zendy; Duong Socheat | Zendy; Chea Nguon | Zendy; Nicholas J. White | Zendy; François Nosten | Zendy; Arjen M. Dondorp | Zendy

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Effect of High-Dose or Split-Dose Artesunate on Parasite Clearance in Artemisinin-Resistant Falciparum Malaria

Author(s) -

Debashish Das,

Rupam Tripura,

Aung Pyae Phyo,

Khin Maung Lwin,

Joel Tärning,

Sue J. Lee,

Warunee Hanpithakpong,

Kasia Stepniewska,

Didier Ménard,

Pascal Ringwald,

Kamolrat Silamut,

Mallika Imwong,

Kesinee Chotivanich,

Poravuth Yi,

Nicholas Day,

Niklas Lindegårdh,

Duong Socheat,

Chea Nguon,

Nicholas J. White,

François Nosten,

Arjen M. Dondorp

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cis958

Subject(s) - artesunate , artemisinin , medicine , parasitemia , malaria , dihydroartemisinin , plasmodium falciparum , mefloquine , pharmacology , interquartile range , immunology

The emergence of Plasmodium falciparum resistance to artemisinins on the Cambodian and Myanmar-Thai borders poses severe threats to malaria control. We investigated whether increasing or splitting the dose of the short-half-life drug artesunate improves parasite clearance in falciparum malaria in the 2 regions.

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