Near-Universal Prevalence of Pneumocystis and Associated Increase in Mucus in the Lungs of Infants With Sudden Unexpected Death | Zendy

Sergio L. Vargas | Zendy; Carolina A. Ponce | Zendy; Miriam Gallo | Zendy; Francisco J. Pérez | Zendy; Jessica Astorga | Zendy; Rebeca Bustamante | Zendy; Magali Chabé | Zendy; Isabelle Durand-Joly | Zendy; Pablo A. Iturra | Zendy; Robert F. Miller | Zendy; El Moukhtar Aliouat | Zendy; Eduardo DeiCas | Zendy

Open Access

Near-Universal Prevalence of Pneumocystis and Associated Increase in Mucus in the Lungs of Infants With Sudden Unexpected Death

Author(s) -

Sergio L. Vargas,

Carolina A. Ponce,

Miriam Gallo,

Francisco J. Pérez,

Jessica Astorga,

Rebeca Bustamante,

Magali Chabé,

Isabelle Durand-Joly,

Pablo A. Iturra,

Robert F. Miller,

El Moukhtar Aliouat,

Eduardo DeiCas

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cis870

Subject(s) - medicine , sudden death , mucus , pediatrics , ecology , biology

Pneumocystis without obvious accompanying pathology is occasionally reported in autopsied infant lungs. Its prevalence and significance are unknown. Interestingly, this mild infection induces a strong activation of mucus secretion-related genes in young immunocompetent rodents that has not been explored in infants. Excess mucus is induced by multiple airway offenders through nonspecific pathways and would explain a cofactor role of Pneumocystis in respiratory disease. We undertook characterization of the prevalence of Pneumocystis and associated mucus in infant lungs.

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