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Lyme disease is transmitted by the bite of the Ixodes scapularis tick, which can also transmit Anaplasma phagocytophilum, the cause of human granulocytic anaplasmosis (HGA). Conflicting data exist on the frequency of coinfection and on whether Lyme-HGA coinfected patients have more symptoms than patients with Lyme disease alone.

Lyme Disease and Human Granulocytic Anaplasmosis Coinfection: Impact of Case Definition on Coinfection Rates and Illness Severity