Single Nucleotide Polymorphisms in ABCC2 Associate With Tenofovir-Induced Kidney Tubular Dysfunction in Japanese Patients With HIV-1 Infection: A Pharmacogenetic Study | Zendy

Takeshi Nishijima | Zendy; Hirokazu Komatsu | Zendy; Koichiro Higasa | Zendy; Misao Takano | Zendy; K. Tsuchiya | Zendy; Tsunefusa Hayashida | Zendy; Shinichi Oka | Zendy; Hiroyuki Gatanaga | Zendy

Open Access

Single Nucleotide Polymorphisms in ABCC2 Associate With Tenofovir-Induced Kidney Tubular Dysfunction in Japanese Patients With HIV-1 Infection: A Pharmacogenetic Study

Author(s) -

Takeshi Nishijima,

Hirokazu Komatsu,

Koichiro Higasa,

Misao Takano,

K. Tsuchiya,

Tsunefusa Hayashida,

Shinichi Oka,

Hiroyuki Gatanaga

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cis772

Subject(s) - medicine , odds ratio , single nucleotide polymorphism , haplotype , genotype , pharmacogenetics , gastroenterology , urinary system , genotyping , genetics , biology , gene

Tenofovir is a widely used antiretroviral drug although it can cause kidney tubular dysfunction (KTD). The aim of this study was to determine the association between polymorphisms in genes encoding drug transporters and KTD in Japanese patients treated with tenofovir.

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