Increased Susceptibility of Pseudomonas aeruginosa to Macrolides and Ketolides in Eukaryotic Cell Culture Media and Biological Fluids Due to Decreased Expression of oprM and Increased Outer-Membrane Permeability | Zendy

Julien M. Buyck | Zendy; Patrick Plésiat | Zendy; H. Traore | Zendy; Francis Vanderbist | Zendy; Paul M. Tulkens | Zendy; Françoise Van Bambeke | Zendy

Open Access

Increased Susceptibility of Pseudomonas aeruginosa to Macrolides and Ketolides in Eukaryotic Cell Culture Media and Biological Fluids Due to Decreased Expression of oprM and Increased Outer-Membrane Permeability

Author(s) -

Julien M. Buyck,

Patrick Plésiat,

H. Traore,

Francis Vanderbist,

Paul M. Tulkens,

Françoise Van Bambeke

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cis473

Subject(s) - microbiology and biotechnology , azithromycin , pseudomonas aeruginosa , minimum inhibitory concentration , bacterial outer membrane , efflux , bacteria , membrane permeability , biology , biochemistry , antibiotics , membrane , escherichia coli , gene , genetics

Macrolides show high minimum inhibitory concentrations (MICs) against Pseudomonas aeruginosa when tested in recommended media (cation-adjusted Muller-Hinton broth [CA-MHB]). Nevertheless, azithromycin is successfully used in cystic fibrosis patients, supposedly because of "nonantibiotic effects."

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