Maternal HIV-1 Disease Progression 18-24 Months Postdelivery According to Antiretroviral Prophylaxis Regimen (Triple-Antiretroviral Prophylaxis During Pregnancy and Breastfeeding vs Zidovudine/Single-Dose Nevirapine Prophylaxis): The Kesho Bora Randomized Controlled Trial
Author(s) -
B. Dioulasso,
Burkina Faso,
N. Méda,
Paulin Fao,
Odette KyZerbo,
Clarisse Gouem,
Paulin Somda,
Hervé Hien,
Paul Ouédraogo,
Dramane Kania,
A Sanou,
I. A. Kossiwavi,
Bintou Sanogo,
Moussa Ouédraogo,
Issa Siribié,
D Valéa,
Samdpawindé Macaire Ouédraogo,
Roselyne Some,
François Rouet,
Nigel Rollins,
L. McFetridge,
K. Naidu,
Stanley Lüchters,
M Reyners,
Elizabeth Irungu,
C. Katingima,
Mary Mwaura,
Gneneyeri Joseph Ouattara,
Kishorchandra Mandaliya,
Sammy Wambua,
Mary Thiongo,
Ruth Nduati,
Junko Kose,
Ephantus Njagi,
Peter Mwaura,
MarieLouise Newell,
Stephen Mepham,
J. Viljoen,
Ruth Bland,
Lulama Mthethwa
Publication year - 2012
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/cis461
Subject(s) - medicine , nevirapine , zidovudine , regimen , breastfeeding , pregnancy , randomized controlled trial , pre exposure prophylaxis , human immunodeficiency virus (hiv) , obstetrics , pediatrics , surgery , viral disease , immunology , antiretroviral therapy , viral load , biology , genetics , syphilis , men who have sex with men
Antiretroviral (ARV) prophylaxis effectively reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV). However, it is unclear whether stopping ARVs after breastfeeding cessation affects maternal HIV disease progression. We assessed 18-24-month postpartum disease progression risk among women in a randomized trial assessing efficacy and safety of prophylactic maternal ARVs.
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