Does Lipid Emulsion Reduce Amphotericin B Nephrotoxicity? A Systematic Review and Meta-analysis | Zendy

Sóstenes Mistro | Zendy; Idalina Maciel | Zendy; R. G. de Menezes | Zendy; Zuinara Pereira Gusmão Maia | Zendy; Robert T. Schooley | Zendy; Roberto Badaró | Zendy

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Does Lipid Emulsion Reduce Amphotericin B Nephrotoxicity? A Systematic Review and Meta-analysis

Author(s) -

Sóstenes Mistro,

Idalina Maciel,

R. G. de Menezes,

Zuinara Pereira Gusmão Maia,

Robert T. Schooley,

Roberto Badaró

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cis290

Subject(s) - nephrotoxicity , medicine , meta analysis , amphotericin b , relative risk , confidence interval , emulsion , pharmacology , gastroenterology , toxicity , antifungal , chemistry , biochemistry , dermatology

This meta-analysis of 13 studies revealed that amphotericin B delivered as a locally prepared lipid emulsion or in liposomes reduced nephrotoxicity to a similar degree, by 18.4% (relative risk [RR], 0.40 [99% confidence interval, .25-.64]; n = 459) and 18.1% (RR, 0.48 [99% CI, .36-.64]); n = 1233), respectively.

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