Patterns of HIV-1 Drug Resistance After First-Line Antiretroviral Therapy (ART) Failure in 6 Sub-Saharan African Countries: Implications for Second-Line ART Strategies | Zendy

Raph L Hamers | Zendy; Kim Sigaloff | Zendy; Annemarie M. J. Wensing | Zendy; Carole L. Wallis | Zendy; Cissy Kityo | Zendy; Margaret Siwale | Zendy; Kishor Mandaliya | Zendy; Prudence Ive | Zendy; M. E. Botes | Zendy; Melanie Wellington | Zendy; Akin Osibogun | Zendy; Wendy Stevens | Zendy; Tobias F. Rinke de Wit | Zendy; Rob Schuurman | Zendy

Open Access

Patterns of HIV-1 Drug Resistance After First-Line Antiretroviral Therapy (ART) Failure in 6 Sub-Saharan African Countries: Implications for Second-Line ART Strategies

Author(s) -

Raph L Hamers,

Kim Sigaloff,

Annemarie M. J. Wensing,

Carole L. Wallis,

Cissy Kityo,

Margaret Siwale,

Kishor Mandaliya,

Prudence Ive,

M. E. Botes,

Melanie Wellington,

Akin Osibogun,

Wendy Stevens,

Tobias F. Rinke de Wit,

Rob Schuurman

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cis254

Subject(s) - medicine , drug resistance , antiretroviral therapy , human immunodeficiency virus (hiv) , drug , hiv drug resistance , cohort , virology , second line , sida , first line , antiretroviral drug , resistance (ecology) , lentivirus , viral load , viral disease , pharmacology , genetics , biology , ecology

Human immunodeficiency virus type 1 (HIV-1) drug resistance may limit the benefits of antiretroviral therapy (ART). This cohort study examined patterns of drug-resistance mutations (DRMs) in individuals with virological failure on first-line ART at 13 clinical sites in 6 African countries and predicted their impact on second-line drug susceptibility.

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