Relationship of In Vitro Susceptibility to Moxifloxacin and In Vivo Clinical Outcome in Bacterial Keratitis | Zendy

Prajna Lalitha | Zendy; Muthiah Srinivasan | Zendy; M. Palanisamy | Zendy; M. Jayahar Bharathi | Zendy; R. Rajaraman | Zendy; Mithunan Ravindran | Zendy; Vicky Cevallos | Zendy; Catherine E. Oldenburg | Zendy; K. J. Ray | Zendy; Christine M. Toutain-Kidd | Zendy; David V. Glidden | Zendy; Michael E. Zegans | Zendy; Stephen D. McLeod | Zendy; Nisha R. Acharya | Zendy; Thomas M. Lietman | Zendy

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Relationship of In Vitro Susceptibility to Moxifloxacin and In Vivo Clinical Outcome in Bacterial Keratitis

Author(s) -

Prajna Lalitha,

Muthiah Srinivasan,

M. Palanisamy,

M. Jayahar Bharathi,

R. Rajaraman,

Mithunan Ravindran,

Vicky Cevallos,

Catherine E. Oldenburg,

K. J. Ray,

Christine M. Toutain-Kidd,

David V. Glidden,

Michael E. Zegans,

Stephen D. McLeod,

Nisha R. Acharya,

Thomas M. Lietman

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cis189

Subject(s) - moxifloxacin , medicine , corneal perforation , streptococcus pneumoniae , visual acuity , keratitis , corneal ulcer , antibiotics , ophthalmology , confidence interval , microbiological culture , surgery , microbiology and biotechnology , bacteria , genetics , biology

For bacterial infections, the susceptibility to antibiotics in vitro has been associated with clinical outcomes in vivo, although the importance of minimum inhibitory concentration (MIC) has been debated. In this study, we analyzed the association of MIC on clinical outcomes in bacterial corneal ulcers, while controlling for organism and severity of disease at presentation.

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