Initial Virologic Response and HIV Drug Resistance Among HIV-Infected Individuals Initiating First-line Antiretroviral Therapy at 2 Clinics in Chennai and Mumbai, India | Zendy

Nitin Hingankar | Zendy; Smita R. Thorat | Zendy; Alaka Deshpande | Zendy; S. Rajasekaran | Zendy; C Chandrasekar | Zendy; Suria Kumar | Zendy; Padmini Srikantiah | Zendy; Devidas N. Chaturbhuj | Zendy; Sharda R. Datkar | Zendy; Pravin S. Deshmukh | Zendy; Smita Kulkarni | Zendy; Suvarna Sane | Zendy; D. C. S. Reddy | Zendy; Renu Garg | Zendy; Michael R. Jordan | Zendy; Sandhya Kabra | Zendy; Srikanth Tripathy | Zendy; Ramesh Paranjape | Zendy

Open Access

Initial Virologic Response and HIV Drug Resistance Among HIV-Infected Individuals Initiating First-line Antiretroviral Therapy at 2 Clinics in Chennai and Mumbai, India

Author(s) -

Nitin Hingankar,

Smita R. Thorat,

Alaka Deshpande,

S. Rajasekaran,

C Chandrasekar,

Suria Kumar,

Padmini Srikantiah,

Devidas N. Chaturbhuj,

Sharda R. Datkar,

Pravin S. Deshmukh,

Smita Kulkarni,

Suvarna Sane,

D. C. S. Reddy,

Renu Garg,

Michael R. Jordan,

Sandhya Kabra,

Srikanth Tripathy,

Ramesh Paranjape

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cis005

Subject(s) - medicine , hiv drug resistance , antiretroviral therapy , viral load , human immunodeficiency virus (hiv) , drug resistance , antiretroviral drug , lost to follow up , virology , microbiology and biotechnology , biology

Human immunodeficiency virus drug resistance (HIVDR) in cohorts of patients initiating antiretroviral therapy (ART) at clinics in Chennai and Mumbai, India, was assessed following World Health Organization (WHO) guidelines. Twelve months after ART initiation, 75% and 64.6% of participants at the Chennai and Mumbai clinics, respectively, achieved viral load suppression of <1000 copies/mL (HIVDR prevention). HIVDR at initiation of ART (P <.05) and 12-month CD4 cell counts <200 cells/μL (P <.05) were associated with HIVDR at 12 months. HIVDR prevention exceeded WHO guidelines (≥ 70%) at the Chennai clinic but was below the target in Mumbai due to high rates of loss to follow-up. Findings highlight the need for defaulter tracing and scale-up of routine viral load testing to identify patients failing first-line ART.

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