Does an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV? | Zendy

Amy C. Justice | Zendy; Matthew S. Freiberg | Zendy; Russell P. Tracy | Zendy; Lewis H. Kuller | Zendy; J. Tate | Zendy; Matthew Bidwell Goetz | Zendy; David A. Fiellin | Zendy; Gary Vanasse | Zendy; Adeel A. Butt | Zendy; Maria C. RodriguezBarradas | Zendy; Cynthia L. Gibert | Zendy; Kris Ann Oursler | Zendy; Steven G. Deeks | Zendy; Kendall Bryant | Zendy

Open Access

Does an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV?

Author(s) -

Amy C. Justice,

Matthew S. Freiberg,

Russell P. Tracy,

Lewis H. Kuller,

J. Tate,

Matthew Bidwell Goetz,

David A. Fiellin,

Gary Vanasse,

Adeel A. Butt,

Maria C. RodriguezBarradas,

Cynthia L. Gibert,

Kris Ann Oursler,

Steven G. Deeks,

Kendall Bryant

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir989

Subject(s) - medicine , monocyte , human immunodeficiency virus (hiv) , inflammation , immunology , mortality rate , cohort , renal function , systemic inflammation

When added to age, CD4 count and human immunodeficiency virus type 1 (HIV-1) RNA alone (Restricted Index), hemoglobin, FIB-4 Index, hepatitis C virus (HCV), and estimated glomerular filtration rate improve prediction of mortality. Weighted and combined, these 7 routine clinical variables constitute the Veterans Aging Cohort Study (VACS) Index. Because nonroutine biomarkers of inflammation (interleukin 6 [IL-6]), coagulation (D-dimer), and monocyte activation (sCD14) also predict mortality, we test the association of these indices and biomarkers with each other and with mortality.

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