Differential Occurrence of Streptococcus pneumoniae Serotype 11E Between Asymptomatic Carriage and Invasive Pneumococcal Disease Isolates Reflects a Unique Model of Pathogen Microevolution | Zendy

J. J. Calix | Zendy; Ron Dagan | Zendy; Stephen I. Pelton | Zendy; Nurit Porat | Zendy; Moon H. Nahm | Zendy

Open Access

Differential Occurrence of Streptococcus pneumoniae Serotype 11E Between Asymptomatic Carriage and Invasive Pneumococcal Disease Isolates Reflects a Unique Model of Pathogen Microevolution

Author(s) -

J. J. Calix,

Ron Dagan,

Stephen I. Pelton,

Nurit Porat,

Moon H. Nahm

Publication year - 2012

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir953

Subject(s) - serotype , streptococcus pneumoniae , carriage , biology , microbiology and biotechnology , pathogen , virology , multilocus sequence typing , pneumococcal infections , genotype , immunology , medicine , gene , genetics , pathology , antibiotics

Streptococcus pneumoniae is a commensal colonizer of the human nasopharynx (NP) that causes disease after evasion of host defenses and dissemination. Pneumococcal strains expressing the newly identified serotype 11E arise from antigenically similar 11A progenitors by genetic inactivation of the O-acetyltransferase gene wcjE. Each 11E strain contains a distinct mutation to wcjE, suggesting that 11E strains are not transmitted among hosts despite their recovery from multiple patients with pneumococcal disease. We investigated whether the presumed lack of transmission of serotype 11E is consistent with its inability to survive in the NP.

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