Additional Drug Resistance in Mycobacterium tuberculosis Isolates From Resected Cavities Among Patients With Multidrug-Resistant or Extensively Drug-Resistant Pulmonary Tuberculosis | Zendy

Russell R. Kempker | Zendy; Alexander S. Rabin | Zendy; Ketino Nikolaishvili | Zendy; Iagor Kalandadze | Zendy; Shota Gogishvili | Zendy; Henry M. Blumberg | Zendy; Sergo Vashakidze | Zendy

Open Access

Additional Drug Resistance in Mycobacterium tuberculosis Isolates From Resected Cavities Among Patients With Multidrug-Resistant or Extensively Drug-Resistant Pulmonary Tuberculosis

Author(s) -

Russell R. Kempker,

Alexander S. Rabin,

Ketino Nikolaishvili,

Iagor Kalandadze,

Shota Gogishvili,

Henry M. Blumberg,

Sergo Vashakidze

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir904

Subject(s) - medicine , tuberculosis , drug resistance , mycobacterium tuberculosis , sputum , multiple drug resistance , drug , extensively drug resistant tuberculosis , microbiology and biotechnology , pharmacology , pathology , biology

The pathogenesis of increasing drug resistance among patients with multidrug-resistant or extensively drug-resistant tuberculosis undergoing treatment is poorly understood. Increasing drug resistance found among Mycobacterium tuberculosis recovered from cavitary isolates compared with paired sputum isolates suggests pulmonary cavities may play a role in the development of worsening tuberculosis drug resistance.

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