Use of a Rapid Test of Pneumococcal Colonization Density to Diagnose Pneumococcal Pneumonia | Zendy

Werner C. Albrich | Zendy; Shabir A. Madhi | Zendy; Peter V. Adrian | Zendy; Nadia van Niekerk | Zendy; T. Mareletsi | Zendy; Clare Cutland | Zendy; Michelle Wong | Zendy; M. Khoosal | Zendy; Alan Karstaedt | Zendy; Pan Zhao | Zendy; Anne M. Deatly | Zendy; Maninder K. Sidhu | Zendy; Kathrin U. Jansen | Zendy; Keith P. Klugman | Zendy

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Use of a Rapid Test of Pneumococcal Colonization Density to Diagnose Pneumococcal Pneumonia

Author(s) -

Werner C. Albrich,

Shabir A. Madhi,

Peter V. Adrian,

Nadia van Niekerk,

T. Mareletsi,

Clare Cutland,

Michelle Wong,

M. Khoosal,

Alan Karstaedt,

Pan Zhao,

Anne M. Deatly,

Maninder K. Sidhu,

Kathrin U. Jansen,

Keith P. Klugman

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir859

Subject(s) - pneumonia , streptococcus pneumoniae , asymptomatic , medicine , pneumococcal pneumonia , real time polymerase chain reaction , sputum , gold standard (test) , community acquired pneumonia , immunology , gastroenterology , microbiology and biotechnology , biology , pathology , gene , tuberculosis , antibiotics , biochemistry

There is major need for a more sensitive assay for the diagnosis of pneumococcal community-acquired pneumonia (CAP). We hypothesized that pneumococcal nasopharyngeal (NP) proliferation may lead to microaspiration followed by pneumonia. We therefore tested a quantitative lytA real-time polymerase chain reaction (rtPCR) on NP swab samples from patients with pneumonia and controls.

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