HIV-1 Dual Infection Is Associated With Faster CD4+ T-Cell Decline in a Cohort of Men With Primary HIV Infection | Zendy

Marion Cornelissen | Zendy; Alexander Pasternak | Zendy; Marlous L. Grijsen | Zendy; Fokla Zorgdrager | Zendy; Marian K. Bakker | Zendy; Pétra Blom | Zendy; Jan M. Prins | Zendy; Suzanne Jurriaans | Zendy; Antoinette C. van der Kuyl | Zendy

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HIV-1 Dual Infection Is Associated With Faster CD4+ T-Cell Decline in a Cohort of Men With Primary HIV Infection

Author(s) -

Marion Cornelissen,

Alexander Pasternak,

Marlous L. Grijsen,

Fokla Zorgdrager,

Marian K. Bakker,

Pétra Blom,

Jan M. Prins,

Suzanne Jurriaans,

Antoinette C. van der Kuyl

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir849

Subject(s) - coinfection , superinfection , cart , medicine , immunology , cohort , disease , viral load , human immunodeficiency virus (hiv) , virology , virus , mechanical engineering , engineering

In vitro, animal, and mathematical models suggest that human immunodeficiency virus (HIV) co- or superinfection would result in increased fitness of the pathogen and, possibly, increased virulence. However, in patients, the impact of dual HIV type 1 (HIV-1) infection on disease progression is unclear, because parameters relevant for disease progression have not been strictly analyzed. The objective of the present study is to analyze the effect of dual HIV-1 infections on disease progression in a well-defined cohort of men who have sex with men.

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