A Comparison of 3 Regimens to Prevent Nevirapine Resistance Mutations in HIV-Infected Pregnant Women Receiving a Single Intrapartum Dose of Nevirapine | Zendy

Russell B. Van Dyke | Zendy; Nicole NgoGiangHuong | Zendy; D. E. Shapiro | Zendy; Lisa M. Frenkel | Zendy; P. Britto | Zendy; Anuvat Roongpisuthipong | Zendy; Ingrid A. Beck | Zendy; P. Yuthavisuthi | Zendy; Sinart Prommas | Zendy; Thanyawee Puthanakit | Zendy; Jullapong Achalapong | Zendy; M. Tiv | Zendy; W. Rasri | Zendy; Tim R. Cressey | Zendy; Robert Maupin | Zendy; Mark Mirochnick | Zendy; Gonzague Jourdain | Zendy

Open Access

A Comparison of 3 Regimens to Prevent Nevirapine Resistance Mutations in HIV-Infected Pregnant Women Receiving a Single Intrapartum Dose of Nevirapine

Author(s) -

Russell B. Van Dyke,

Nicole NgoGiangHuong,

D. E. Shapiro,

Lisa M. Frenkel,

P. Britto,

Anuvat Roongpisuthipong,

Ingrid A. Beck,

P. Yuthavisuthi,

Sinart Prommas,

Thanyawee Puthanakit,

Jullapong Achalapong,

M. Tiv,

W. Rasri,

Tim R. Cressey,

Robert Maupin,

Mark Mirochnick,

Gonzague Jourdain

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir798

Subject(s) - nevirapine , zidovudine , medicine , didanosine , stavudine , lamivudine , regimen , virology , viral load , lopinavir , resistance mutation , gastroenterology , human immunodeficiency virus (hiv) , virus , viral disease , biology , reverse transcriptase , hepatitis b virus , antiretroviral therapy , rna , biochemistry , gene

Intrapartum single-dose (SD) nevirapine (NVP) reduces perinatal transmission of human immunodeficiency virus (HIV) infection but selects for NVP-resistant virus, which compromises subsequent NVP-based therapy. A 1-week "tail" of lamivudine and zidovudine after SD-NVP decreases the risk of resistance. We hypothesized that increasing the duration or potency of the tail would further reduce this risk to <10%, using a sensitive assay to measure resistance.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research