The Effect of AIDS Clinical Trials Group Protocol 5164 on the Time From Pneumocystis jirovecii Pneumonia Diagnosis to Antiretroviral Initiation in Routine Clinical Practice: A Case Study of Diffusion, Dissemination, and Implementation | Zendy

Elvin Geng | Zendy; James S. Kahn | Zendy; Olivia Chang | Zendy; C. Bradley Hare | Zendy; K. A. Christopoulos | Zendy; David J. Jones | Zendy; Maya Petersen | Zendy; Steven G. Deeks | Zendy; Diane V. Havlir | Zendy; Monica Gandhi | Zendy

Open Access

The Effect of AIDS Clinical Trials Group Protocol 5164 on the Time From Pneumocystis jirovecii Pneumonia Diagnosis to Antiretroviral Initiation in Routine Clinical Practice: A Case Study of Diffusion, Dissemination, and Implementation

Author(s) -

Elvin Geng,

James S. Kahn,

Olivia Chang,

C. Bradley Hare,

K. A. Christopoulos,

David J. Jones,

Maya Petersen,

Steven G. Deeks,

Diane V. Havlir,

Monica Gandhi

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir608

Subject(s) - medicine , pneumocystis jirovecii , pneumocystis pneumonia , clinical trial , clinical practice , protocol (science) , pneumonia , intensive care medicine , human immunodeficiency virus (hiv) , family medicine , pathology , alternative medicine

Diffusion, dissemination, and implementation of scientific evidence into routine clinical practice is not well understood. The Adult AIDS Clinical Trials Group (ACTG) Protocol 5164 showed that early antiretroviral therapy (ART; ie, within 14 days) after diagnosis of an opportunistic infection improved clinical outcomes, compared with later initiation. Subsequently, the San Francisco General Hospital (SFGH) HIV/AIDS Service performed the SFGH 5164 Initiative to disseminate and implement the findings of ACTG 5164.

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