Initial Recovery and Rebound of Type F Intestinal Colonization Botulism After Administration of Investigational Heptavalent Botulinum Antitoxin | Zendy

Ryan Fagan | Zendy; Karen Neil | Zendy; R. Sasich | Zendy; Carolina Lúquez | Zendy; Hamas Asaad | Zendy; S. Maslanka | Zendy; Wael A. Khalil | Zendy

Open Access

Initial Recovery and Rebound of Type F Intestinal Colonization Botulism After Administration of Investigational Heptavalent Botulinum Antitoxin

Author(s) -

Ryan Fagan,

Karen Neil,

R. Sasich,

Carolina Lúquez,

Hamas Asaad,

S. Maslanka,

Wael A. Khalil

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir550

Subject(s) - antitoxin , botulism , medicine , clearance , immunology , virology , microbiology and biotechnology , toxin , biology , urology

Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.

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