Severity of Disease and Clinical Outcomes in Patients With Hospital-Acquired Pneumonia Due to Methicillin-Resistant Staphylococcus aureus Strains Not Influenced by the Presence of the Panton-Valentine Leukocidin Gene | Zendy

Paula Peyrani | Zendy; Marty Allen | Zendy; Timothy L. Wiemken | Zendy; Nadia Z. Haque | Zendy; Marcus Zervos | Zendy; Kimbal D. Ford | Zendy; Ernesto G. Scerpella | Zendy; Julie E. Mangino | Zendy; Daniel H. Kett | Zendy; Julio A. Ramírez | Zendy

Open Access

Severity of Disease and Clinical Outcomes in Patients With Hospital-Acquired Pneumonia Due to Methicillin-Resistant Staphylococcus aureus Strains Not Influenced by the Presence of the Panton-Valentine Leukocidin Gene

Author(s) -

Paula Peyrani,

Marty Allen,

Timothy L. Wiemken,

Nadia Z. Haque,

Marcus Zervos,

Kimbal D. Ford,

Ernesto G. Scerpella,

Julie E. Mangino,

Daniel H. Kett,

Julio A. Ramírez

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir541

Subject(s) - medicine , panton–valentine leukocidin , leukocidin , methicillin resistant staphylococcus aureus , pneumonia , staphylococcus aureus , antibiotics , community acquired pneumonia , microbiology and biotechnology , biology , bacteria , genetics

Patients with community-acquired pneumonia (CAP) infected with methicillin-resistant Staphylococcus aureus (MRSA) strains carrying the Panton-Valentine leukocidin (PVL) gene have severe clinical presentation and poor clinical outcomes. Antibiotics that suppress toxin production have been suggested for the management of these patients. The objective of this study was to compare the severity of disease and clinical outcomes of patients with hospital-acquired pneumonia/ventilator-associated pneumonia (HAP/VAP) infected with MRSA carrying the PVL gene with those patients infected with MRSA strains that do not carry the PVL gene.

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